ASSOCIAÇÃO ENTRE LESÕES DE HPV E OS CARCINOMAS GENITAIS E DA CAVIDADE ORAL: UMA REVISÃO NARRATIVA

Autores

  • Camila Melo Mesquita Universidade Federal do Ceará (UFC)
  • Anne Diollina Araujo Morais Universidade Federal do Ceará (UFC)
  • Ana Ericka de Araújo Mouta Universidade Federal do Ceará (UFC)
  • Delinne Costa e Silva Universidade Federal do Ceará (UFC)
  • Ealber Carvalho Macedo Luna Universidade Federal do Ceará (UFC)
  • Filipe Nobre Chaves Universidade Federal do Ceará (UFC)
  • José Juvenal Linhares Universidade Federal do Ceará
  • Denise Hélen Imaculada Pereira de Oliveira Universidade Federal do Ceará

DOI:

https://doi.org/10.25110/arqsaude.v27i10.2023-001

Palavras-chave:

HPV, Carcinogênese, Câncer Oral, Câncer Cervical, Câncer Peniano, Câncer Anal, Neoplasias Anus

Resumo

Os Papilomavírus Humano (HPVs) são membros da família Papilomaviridae. O vírus destaca-se pelo seu tropismo por células epiteliais, infectando exclusivamente mucosa epitelial e cutânea. O HPV-16 e HPV-18 são subtipos classificados como de alto risco, conhecidos por sua oncogenicidade, fortemente associados aos cânceres anais, genitais e de orofaringe. Lesões por HPV representam um grande grupo de doenças sexualmente transmissíveis. O objetivo do presente estudo consistiu em realizar uma revisão narrativa sobre a associação entre lesões por HPV e carcinomas genitais e da cavidade oral. Realizamos uma busca na base de dados eletrônicos PubMed, Lilacs, Scielo, Medline e Google Scholar, sendo utilizados artigos publicados entre os anos de 2017-2021, ao fim, foram selecionados 36 artigos. Grande parte das infecções por HPV são subclínicas, ou seja, não apresentam sintomatologia importante e tendem a desaparecer espontaneamente. Desta forma, faz-se necessário ter conhecimento a respeito dos aspectos clínicos e comportamentais dessas lesões, possibilitando o diagnóstico precoce, evitando a evolução para estágios mais invasivos, favorecendo um tratamento efetivo e melhor prognóstico.

Biografia do Autor

José Juvenal Linhares, Universidade Federal do Ceará

Professor Doutor do Programa de Mestrado em Ciências da Saúde – Universidade Federal do Ceará campus Sobral

Referências

AFONSO, L. A. et al. Human papillomavirus, Epstein‐Barr virus, and methylation sta-tus of p16ink4a in penile cancer. Journal of medical virology, v. 89, n. 10, p. 1837-1843, 2017.

ANTONSSON, A. et al. Natural history of oral HPV infection: Longitudinal analyses in prospective cohorts from Australia. International journal of cancer, v. 148, n. 8, p. 1964-1972, 2021.

ASSIS, R.C.; RIBEIRO, M.S.; FERREIRA, L.P. et al. Associação entre o câncer de boca e a presença do HPV- Revisão Sistemática. Revisa, v. 9, n.2, p.344-56, 2020.

BALASUBRAMANIAM, S. D. et al. Key molecular events in cervical cancer deve-lopment. Medicina, v. 55, n. 7, p. 384, 2019.

BIJINA, B. R. et al. Detection of human papilloma virus in potentially malignant and malignant lesions of the oral cavity and a study of associated risk factors. South Asian Journal of Cancer, v. 5, n. 04, p. 179-181, 2016.

BLAHAK, J. et al. HPV, protein p16 and squamous cell carcinoma of the oral ca-vity. Biomedical Papers of the Medical Faculty of Palacky University in Olomouc, v. 164, n. 3, 2020.

CHAKROBARTY, B. et al. Relationship among tobacco habits, human papilloma virus (HPV) infection, p53 polymorphism/mutation and the risk of oral squamous cell carci-noma. Journal of oral and maxillofacial pathology, v. 18, n. 2, p. 211, 2014.

CLARKE, M. A.; WENTZENSEN, N. Strategies for screening and early detection of anal cancers: a narrative and systematic review and meta‐analysis of cytology, HPV tes-ting, and other biomarkers. Cancer cytopathology, v. 126, n. 7, p. 447-460, 2018.

DHANAPAL, R. et al. High-risk human papilloma virus in archival tissues of oral pathosis and normal oral mucosa. Contemporary Clinical Dentistry, v. 6, n. 2, p. 148, 2015.

FERNÁNDEZ-LÓPEZ, Claudia; MORALES-ANGULO, Carmelo. Otolaryngological lesions secondary to oral sex. Acta Otorrinolaringológica Española, v. 68, n. 3, p. 169-180, 2017.

GALVIS, M. M. et al. Expression of cell cycle proteins according to HPV status in oral squamous cell carcinoma affecting young patients: a pilot study. Oral surgery, oral medicine, oral pathology and oral radiology, v. 125, n. 4, p. 317-325, 2018.

GIPSON, B. J. et al. Sensitivity and specificity of oral HPV detection for HPV-positive head and neck cancer. Oral oncology, v. 77, p. 52-56, 2018.

GRIFFIN, L. M.; CICCHINI, L.; PYEON, D. Human papillomavirus infection is inhi-bited by host autophagy in primary human keratinocytes. Virology, v. 437, n. 1, p. 12-19, 2013.

GUPTA, Sadhana M.; MANIA-PRAMANIK, Jayanti. RETRACTED ARTICLE: Mo-lecular mechanisms in progression of HPV-associated cervical carcinogenesis. Journal of biomedical science, v. 26, n. 1, p. 1-19, 2019.

HERRERO, R.; CASTELLSAGUÉ, X.; PAWLITA, M. et al. Human papillomavirus and oral cancer: the International Agency for Research on Cancer multicenter study. J Natl Cancer Inst, v. 95, p. 1772-1783, 2003.

HU, Z.; MA, D. The precision prevention and therapy of HPV‐related cervical cancer: new concepts and clinical implications. Cancer medicine, v. 7, n. 10, p. 5217-5236, 2018.

ILIE, M.M.T; SUZUKI, L.E; YOSHIDA, C.S; LOPES, D.C, CONSOLARO, M.E.L. Avaliação dos critérios morfológicos clássicos e não clássicos de HPV no diagnóstico colpocitológico. Arq. Ciênc. Saúde Unipar, v.5, n.3, p.259-266,2001.

LI, Y. et al. Effect of human papillomavirus seropositivity and E2F2 promoter variants on risk of squamous cell carcinomas of oropharynx and oral cavity. Carcinogenesis, v. 37, n. 11, p. 1070-1078, 2016.

LIN, C.; FRANCESCHI, S,; CLIFFORD, G. M. Human papillomavirus types from infection to cancer in the anus, according to sex and HIV status: a systematic review and meta-analysis. The Lancet Infectious Diseases, v. 18, n. 2, p. 198-206, 2018.

LUM, C et al. A 2020 update of anal cancer: the increasing problem in women and ex-panding treatment landscape. Expert review of gastroenterology & hepatology, v. 14, n. 8, p. 665-680, 2020.

MOSMANN, J. P. et al. Human papillomavirus and Chlamydia trachomatis in oral and genital mucosa of women with normal and abnormal cervical cytology. BMC Infectious Diseases, v. 21, n. 1, p. 1-8, 2021.

OYERVIDES-MUÑOZ, M. A. et al. Understanding the HPV integration and its pro-gression to cervical cancer. Infection, Genetics and Evolution, v. 61, p. 134-144, 2018.

PÉREZ-QUINTANILLA, M. et al. High prevalence of human papillomavirus and Eu-ropean variants of HPV 16 infecting concomitantly to cervix and oral cavity in HIV positive women. PLoS One, v. 15, n. 4, p. e0227900, 2020.

PRIGGE, E. S.; VON K. D. M; REUSCHENBACH, M. Clinical relevance and impli-cations of HPV-induced neoplasia in different anatomical locations. Mutation Rese-arch/Reviews in Mutation Research, v. 772, p. 51-66, 2017.

SALEH, W. et al. Localization and characterization of human papillomavirus‐16 in oral squamous cell carcinoma. Oral Diseases, 2021.

SANTACROCE, L. et al. Focus on HPV infection and the molecular mechanisms of oral carcinogenesis. Viruses, v. 13, n. 4, p. 559, 2021.

SILVIA; B. L.; ALEMANY, L. HPV in genital cancers (at the exception of cervical cancer) and anal cancers. La Presse Médicale, v. 43, n. 12, p. e423-e428, 2014.

SCHLENKER, B.; SCHNEEDE, P. The role of human papilloma virus in penile cancer prevention and new therapeutic agents. European urology focus, v. 5, n. 1, p. 42-45, 2019.

SHIN, M. K. et al. Activating mutations in Pik3ca contribute to anal carcinogenesis in the presence or absence of HPV-16 oncogenes. Clinical Cancer Research, v. 25, n. 6, p. 1889-1900, 2019.

SINGH, V. et al. p16 and p53 in HPV‐positive versus HPV‐negative oral squamous cell carcinoma: do pathways differ?. Journal of Oral Pathology & Medicine, v. 46, n. 9, p. 744-751, 2017.

SIKKA, S.; SIKKA, P. Association of human papilloma virus 16 infection and p53 polymorphism among tobacco using oral leukoplakia patients: A clinicopathologic and genotypic study. International Journal of Preventive Medicine, v. 5, n. 4, p. 430, 2014.

TANG, K. D. et al. Oral HPV16 prevalence in oral potentially malignant disorders and oral cavity cancers. Biomolecules, v. 10, n. 2, p. 223, 2020.

THORSTEINSSON, K. et al. Prevalence of cervical, oral, and anal human papillomavi-rus infection in women living with HIV in Denmark–The SHADE cohort stu-dy. Journal of Clinical Virology, v. 105, p. 64-71, 2018.

VILLA, L. L. Viral carcinogenesis: virus implicated in cancer. In: BMC proceedings. BioMed Central, p. 1-1, 2013.

ZAMMIT, A. P. et al. Examining the contribution of smoking and HPV towards the etiology of oral cavity squamous cell carcinoma using high-throughput sequencing: A prospective observational study. PLoS One, v. 13, n. 10, p. e0205406, 2018.

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Publicado

09-10-2023

Como Citar

MESQUITA, Camila Melo; MORAIS, Anne Diollina Araujo; MOUTA, Ana Ericka de Araújo; E SILVA, Delinne Costa; LUNA, Ealber Carvalho Macedo; CHAVES, Filipe Nobre; LINHARES, José Juvenal; DE OLIVEIRA, Denise Hélen Imaculada Pereira. ASSOCIAÇÃO ENTRE LESÕES DE HPV E OS CARCINOMAS GENITAIS E DA CAVIDADE ORAL: UMA REVISÃO NARRATIVA. Arquivos de Ciências da Saúde da UNIPAR, [S. l.], v. 27, n. 10, p. 5468–5484, 2023. DOI: 10.25110/arqsaude.v27i10.2023-001. Disponível em: https://revistas.unipar.br/index.php/saude/article/view/10613. Acesso em: 26 dez. 2024.

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